食道扁平上皮癌のGWAS

最新のNature Geneticsで食道扁平上皮癌のGWASが中国から出た。これ日本人にも当てはまるのであろうか？

PLCE1 at 10q23
C20orf54 at 20p13

Nature Genetics 42, 759 - 763 (2010) 
Published online: 22 August 2010 | doi:10.1038/ng.648

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54

Li-Dong Wang1,2他

Abstract
We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (PHan combined for ESCC = 7.46 × 10−56, odds ratio (OR) = 1.43; PUygur-Kazakh for ESCC = 5.70 × 10−4, OR = 1.53) and C20orf54 at 20p13 (PHan combined for ESCC = 1.21 × 10−11, OR = 0.86; PUygur-Kazakh for ESCC = 7.88 × 10−3, OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, PHan for GCA = 1.74 × 10−39, OR = 1.55 and C20orf54, PHan for GCA = 3.02 × 10−3, OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.