前立腺がんとGWA：理研と東大による

東大と理研による前立腺癌にかかりやすい多型：最新号のNature Genetics

Nature Genetics | Letter

Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

Ryo Takata, Shusuke Akamatsu, Michiaki Kubo, Atsushi Takahashi, Naoya Hosono, Takahisa Kawaguchi, Tatsuhiko Tsunoda, Johji Inazawa, Naoyuki Kamatani, Osamu Ogawa, Tomoaki Fujioka, Yusuke Nakamura & Hidewaki Nakagawa

Journal name:　Nature Genetics
Received　26 February 2010
Accepted　06 July 2010
Published online　01 August 2010

• Prostate cancer is one of the most common malignancies in males throughout the world¹, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P 10⁻⁷ and ten SNPs at P <> 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (λ-corrected probability P_GC = 3.9 × 10⁻¹⁸), GPRC6A/RFX6 (P_GC = 1.6 × 10⁻¹²), 13q22 (P_GC = 2.8 × 10⁻⁹), C2orf43 (P_GC = 7.5 × 10⁻⁸) and FOXP4 (P_GC = 7.6 × 10⁻⁸). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.

• 欧米の研究で前立腺がんとの関連が知られる３１カ所のＳＮＰのうち、１９カ所が日本人と関係していることが判明。また、日本人にのみ関連する５ カ所の新たなＳＮＰを見つけ、うち１カ所は、性ホルモンを作る遺伝子に関連していた。これら計２４カ所のＳＮＰのいずれかを持つ人は、通常の人より １．１３～１．７５倍前立腺がんにかかりやすいとのこと　（やはり低いなこの値）