子宮平滑筋腫とMED12遺伝子変異のその後

良性腫瘍における高頻度遺伝子変異である。４報出ているのに気がついた。

1. Mutational analysis of MED12 exon 2 in uterine leiomyoma and other common tumors.
   Je EM, Kim MR, Min KO, Yoo NJ, Lee SH.
   
   Int J Cancer. 2012 Apr 24. doi: 10.1002/ijc.27610.
   
   
2. Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas.McGuire MM, Yatsenko A, Hoffner L, Jones M, Surti U, Rajkovic A.

   PLoS One. 2012;7(3):e33251. 2012 Mar 12.

3. MED12 mutations in uterine fibroids-their relationship to cytogenetic subgroups.Markowski DN, Bartnitzke S, Löning T, Drieschner N, Helmke BM, Bullerdiek J
   
   .Int J Cancer. 2012 Jan 5.

4. MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.Mäkinen N, Mehine M, Tolvanen J, Kaasinen E, Li Y, Lehtonen HJ, Gentile M, Yan J, Enge M, Taipale M, Aavikko M, Katainen R, Virolainen E, Böhling T, Koski TA, Launonen V, Sjöberg J, Taipale J, Vahteristo P, Aaltonen LA.
   
   Science. 2011 Oct 14;334(6053):252-5. 2011 Aug 25.